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Categories: Peptides & Proteins / Proteins

Product name			Recombinant Mouse Stem Cell Factor (KITLG)
Catalog No			IGX-RP226
Supplier’s Catalog No			IGX-RP226
Supplier			ImuGeX
Source antigen			CHO cells
Reactivity			Mouse
Cross reactivity
Applications
Molecular weight			18

Storage			-70°C
Other names			SCF, Kit ligand, c-Kit ligand, Hematopoietic growth factor KL, Mast cell growth factor, MGF, Steel factor
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Recombinant Stem cell factor was lyophilized from a 0.2 μm filtered solution in 20mM Tris, 5% trehalose, pH 7.5.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotential stem cells. It has been suggested that SCF is essential for optimal production of various hematopoietic lineages, mainly because of its ability to prevent apoptosis when it co-stimulates with other cytokines. The receptor for SCF, designated SCFR(CD117), is the oncogene designated as KIT. The biological activities of SCF are synergised considerably by colony stimulating factors GM-CSF and G-CSF, and also by IL-7, Epo and some other growth and differentiation factors. In combination with IL-7 SCF stimulates the proliferation of pre-B cells. SCF is also a potent chemoattractant for cells (see also: Chemotaxis), for example, mast cells, expressing the kit receptor. One response to SCF in these cells is a characteristic rearrangement of the actin filaments of the cytoskeleton.