Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			IL-3, Hematopoietic growth factor, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor <br/>Recombinant Human Interleukin-3 (IL3)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Recombinant Interleukin-3 was lyophilized from a 0.2 μm filtered PBS solution pH 7.0.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			IL-3 is produced mainly by T cells following cell activation by antigens and mitogens, but also by keratinocytes, natural killer cells, mast cells, endothelial cells, and monocytes. The analysis of bacterial-derived recombinant IL-3 shows that glycosylation is not required for the activity of IL-3. IL-3 sequences are evolutionarily less well conserved. Human and murine IL-3 show approximately 29 % homology at the protein level while murine and rat IL-3 show approximately 54% homology. IL-3-alpha and IL-3-beta are two isoforms of rat IL-3. IL-3 receptors are expressed on macrophages, mast cells, eosinophils, megakaryocytes, basophils, bone marrow progenitor cells, and various myeloid leukemia cells. IL-3/receptor complexes have a Kdis of 10-9 - 10-10 M. Binding of IL-3 to its receptor causes specific phosphorylation of a 150 kDa membrane glycoprotein.