Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			Interleukin-27 subunit alpha, IL-27 subunit alpha, IL-27-A, IL27-A, p28<br/>Recombinant Human Interleukin-27 (IL27)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Recombinant Human Interleukin-27 was lyophilized from a 0.2 μm filtered PBS solution pH 7.4.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			IL-27 is a cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL-17 producing helper T cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.