Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			GMCSF, Colony-stimulating factor, CSF, Molgramostin, Sargramostim, pluripoietin-alpha, GMCSF <br/>Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor (CSF2)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.0
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			GM-CSF is a hematopoietic growth factor that is produced by endothelial cells, monocytes, fibroblasts and T-lymphocytes following their activation by antigens or mitogens. GM-CSF stimulates the development of macrophages and neutrophils and plays a role in the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. Approximately 90% of the secreted colony stimulating activities are due to GM-CSF. While non-glycosylated and glycosylated GM-CSF show similar activities in vitro, fully glycosylated GM-CSF is biologically more active in vivo compared to its non-glycosylated counterpart. Human and murine GM-CSF are species-specific and therefore, exhibit no cross-reactivity. Recombinant Human GM-CSF is a glycosylated, monomeric protein (contains intra-chain disulfide bonds) that migrates at approximately 25 kDa in a reducing SDS-PAGE.