Recombinant Human G-CSF (CSF3)
Catalog No : IGX-RP202
1458.43€
0.00€
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| Product name | Recombinant Human G-CSF (CSF3) | ||
|---|---|---|---|
| Catalog No | IGX-RP202 | ||
| Supplier’s Catalog No | IGX-RP202 | ||
| Supplier | ImuGeX | ||
| Source antigen | CHO cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 19 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | GCSF, Pluripoietin, INN=Filgrastim, INN=Lenograstim, C17orf33, GCSF<br/>Recombinant Human Granulocyte Colony-Stimulating Factor (CSF3) | ||
| Grade | Highly Purified | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Form | Recombinant G-CSF was lyophilized from a 0.2 μm filtered PBS solution pH 7.0. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Description | G-CSF is secreted by monocytes, macrophages, and neutrophils after cell activation. It is produced also by stromal cells, fibroblasts, and endothelial cells. Epithelial carcinomas, acute myeloid leukemia cells and various tumor cell lines. The synthesis of G-CSF can be induced by bacterial endotoxins, TNF, IL-1 and GM-CSF. Comparison of the primary sequence of G-CSF with those of the two other colony stimulating factors, GM-CSF and M-CSF, shows that the three factors are not related to each other. Murine and human G-CSF show a sequence homology of approximately 70% at the DNA level and of 72% at the protein level. The G-CSF receptor, CD114, is expressed on all cells of the neutrophils and granulocytes lineage. It is expressed also in placenta cells, endothelial cells and various carcinoma cell lines. Human G-CSF is active in murine cells and vice versa. G-CSF stimulates the proliferation and differentiation of hematopoietic progenitor cells committed to the neutrophils and granulocytes lineage in a dose-dependent manner. G-CSF synergises with some other cytokines, including GM-CSF and IL-4. GM-CSF and G-CSF are required, for example, to develop neutrophilic colonies in vitro. The concerted action of G-CSF and Epo is required to support the growth of mixed colonies of the early erythroid progenitors. A combination of IL-4 with G-CSF has been shown to lead to synergistic suppression of the growth of some human leukemic cell lines. | ||
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