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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor<br/>Recombinant Human Neurotrophin-3 (NTF3)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Recombinant NT-3 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			NT-3 is found in neurons of the central nervous system. NT-3 is expressed also in muscles and its expression is down-regulated in denervated muscles. Many human gliomas express and secrete NT-3 into the conditioned medium. Some protein domains of NT-3 are identical with those of NGF and BDNF. NT-3 selectively supports the survival of neuronal cell populations. NT-3 has been shown recently to prevent death of cultured embryonic rat spinal motor neurons at picomolar concentrations. NT-3 has been shown to enhance sprouting of corticospinal tract during development and after adult spinal cord lesion. The activities of NT-3 and BDNF are additive in some systems. The biological activities of NT-3 are mediated by a receptor belonging to the trk family of receptors with intrinsic tyrosine-specific protein kinase activity. NT-3 only binds weakly to the trk receptor which is a high-affinity receptor for NGF.