Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			IL-31<br/>Recombinant Human Interleukin-31 (IL31)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Recombinant Interleukin-31 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			IL-31 is a recently discovered helical cytokine, belonging to the gp130/IL-6 cytokine family. The receptors for IL-6 family are type I receptors, and they share a number of common structural motifs, such as the cytokine-binding domain with two pairs of conserved cysteine residues and a WSXWS sequence motif in the extracellular domain. IL-31 is expressed preferentially by activated Th2 CD4+ T cells, signaling through a heterodimeric receptor complex composed of IL-31RA and OSMR. Recent studies in both humans and mice have suggested a link between IL-31/IL-31R expression and skin inflammation although the functional significance of endogenous IL-31/IL-31R interactions in influencing innate and adaptive immune responses remains unknown.